The Dongola Times

(Anachronistic) Dispatches from the Kingdom of Makuria.
31st of May, 2013

Introducing Cannabidiol

I recently started the Uganda Medical Cannabis Association. It is mainly just a mailing list discussion group thingy. The Google Group is called Cannabidiol. Why did I pick that name? Example:

Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that are yet to be completely identified. CBD acts in some experimental models as an anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic, anxiolytic and antipsychotic agent, and is therefore a potential medicine for the treatment of neuroinflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia, respectively. The neuroprotective potential of CBD, based on the combination of its anti-inflammatory and anti-oxidant properties, is of particular interest and is presently under intense preclinical research in numerous neurodegenerative disorders. In fact, CBD combined with Δ(9)-tetrahydrocannabinol is already under clinical evaluation in patients with Huntington's disease to determine its potential as a disease-modifying therapy. The neuroprotective properties of CBD do not appear to be exerted by the activation of key targets within the endocannabinoid system for plant-derived cannabinoids like Δ(9)-tetrahydrocannabinol, i.e. CB(1) and CB(2) receptors, as CBD has negligible activity at these cannabinoid receptors, although certain activity at the CB(2) receptor has been documented in specific pathological conditions (i.e. damage of immature brain). Within the endocannabinoid system, CBD has been shown to have an inhibitory effect on the inactivation of endocannabinoids (i.e. inhibition of FAAH enzyme), thereby enhancing the action of these endogenous molecules on cannabinoid receptors, which is also noted in certain pathological conditions. CBD acts not only through the endocannabinoid system, but also causes direct or indirect activation of metabotropic receptors for serotonin or adenosine, and can target nuclear receptors of the PPAR family and also ion channels.

http://www.ncbi.nlm.nih.gov/pubmed/22625422

It should be noted that, even though cannabidiol is naturally-occurring in cannabis (weed, marijuana, pot, whatever), it has been patented by the US government. Of course, the American government has found (through the NCI) that marijuana also helps with cancer and poor appetite, but fuck it. It helps with diabetes and glaucoma and so on and so forth. This plant seems to fix many diseases (because every cell has CB receptors), but unfortunately it is also fun to get high on weed, so fuck it. This thing is illegal, but if life itself is illegal, do not try to obey such laws. What God gave, no man can take away. Be confident. Use your medicine.